This error in usually appears when the game’s DRM (SafeDisc) checks for the original disc in a physical DVD/CD drive, but none is found — often because:
PES 6 relies heavily on Windows Registry entries to understand where the game is installed and where the data files are located. If you moved the game folder or reinstalled Windows, these entries might be broken. Create a new text document on your desktop. pes 6 no cd dvdrom drive found verified