Destroy All Humans! is a complete remake of the 2005 original. Released on the Switch in June 2021, this version tasks you with harvesting human DNA and dismantling the US government in a satire of 1950s Americana. The game features a full roster of wacky weaponry—from the classic Zap-O-Matic and Disintegrator Ray to the infamous Anal Probe—and psychic powers like psychokinesis that allow you to hurl enemies and objects. You can also take to the skies in your flying saucer, obliterating humanity’s primitive architecture from above.

While the original Switch hardware cannot maintain 60 FPS, there are mods and codes available for PC emulators (like the PCSX2 wiki notes for the PS2 version). A code exists to "unlock 60 FPS," but it requires hardware overclocking (EE Cyclerate) to be stable. On the native Switch v1.0.1?

If you are looking to pick up the game now or pre-order the upcoming version, several retailers offer various editions: Destroy All Humans! (Standard Edition) : Available at for $39.99. Used physical copies can be found at for approximately $14.99. Nintendo Switch 2

The Destroy All Humans! Switch NSP Update is a necessity for a seamless experience. It fixes the memory leaks that caused crashes during extended play sessions and tightens the visual presentation. For fans of Crypto-137 looking to destroy humanity on the go, the update ensures that the only thing crashing is the humans' cars—not your Switch.