The core gimmick of the sequel lies in its ensemble cast of parodied American cinematic and comic villains. The enemies Wonder Lady faces include bootleg or highly stylized interpretations of:

The series frequently features performers costumed as parodies of character icons such as The Joker, the Terminator, the Predator, and Jason Voorhees .

Wonder Lady VS American Monsters 2 is a prime example of GIGA’s unique charm, deconstructing and reconstructing Western pop culture icons through a Japanese lens.

Despite the fantasy nature of the film, the stunt work and choreography require significant endurance. Hatano excels in the "suit-acting" portions, conveying the struggle and eventual exhaustion of a hero pushed to her limits.